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innervate the ARC, PVN, VMH and LHA, where various subtypes of serotonin receptor are expressed. Serotonin neurones express leptin receptors, while the serotonin inputs to the ARC supply both NPY/AgRP and melanocortin neurones (which carry 5HT1B and 5HT2C receptors, respectively) and apparently act to enhance melanocortin activity over NPY (Figure 6.14). Serotonin powerfully inhibits eating and stimulates energy expenditure, effects which have been exploited in various anti-obesity drugs such as fen uramine (now obsolete) and sibutramine (see 17). The main receptor subtype mediating the eating-inhibitory effect in rats and humans is apparently 5HT2C. As mentioned above, dopamine plays an important role in stimulating eating through the reward pathways.

is known to stimulate myocardial growth and can induce pronounced LVH in the rat, acting either directly or via the IGF-1 receptor and/or by increasing IGF-1 bioavailability (Tanaka, Ryoke and Hongo, 1998; Delaughter et al., 1999). As already mentioned, hyperinsulinaemia increases renal sodium retention and blood volume (DeFronzo et al., 1975), and may act centrally to stimulate sympathetic out ow and peripheral vasoconstriction (Kamide, Rakugi and Higaki, 2002; Greenwood et al., 2001); these effects would increase both volume and pressure loading on the left ventricle.

Going the other direction, Python provides two built-in functions to retrieve a line of text from standard input, which by default comes from the user s keyboard. The examples in this section use italics for text you enter in response to the prompts.

CREATE OR REPLACE PACKAGE hello_pkg AS FUNCTION hello_plsql (param NUMBER) RETURN VARCHAR2; END hello_pkg;

You can control the display of xref layers so that you see only those layers you need. Several features let you control the process of displaying xrefs, making it easier to see only part of an xref and speeding up the display of very large xrefs.

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The transformation that occurs as data moves from the operational environment to the data warehouse environment is complex. There is a change in DBMS, a change in operating systems, a change in hardware architecture, a change in semantics, a change in coding, and so forth. Many, many considerations are involved in the movement of data from the operational environment to the data warehouse environment. The creation of a data warehouse record is triggered by an activity or an event that has occurred in the operational environment. In some cases, an event (such as a sale) has occurred. In other cases, the regular passage of time has occurred, such as the end of the month or the end of the week. A profile record is a composite record made up of many different historical activities. The profile record is a composite representation of data. The star join is a database design technique that is sometimes mistakenly applied to the data warehouse environment. The star join multidimensional approach is an approach where database design is based on the occurrences of data within a subject area and how that data will be accessed. Star join design applies to the world of data marts, not the world of data warehouses. It is a mistake to build a data warehouse with a star join because the data warehouse will end up being optimal for one set of users at the expense of everyone else.

7. Repeat the DIMANGULAR command. At the Select arc, circle, line, or <specify vertex>: prompt, pick the arc at 6. At the Specify dimension arc line location or [Mtext/Text/Angle]: prompt, pick a location for the dimension line. 8. Choose Arc Length from the Dimension toolbar. At the Select arc or polyline arc segment: prompt, again pick the arc at 6. At the Specify arc length dimension location, or [Mtext/Text/Angle/Partial]: prompt, pick a location for the dimension line further out than the previous dimension that you drew.

P1: KOA WY050-04 WY050-Ulick-v4 September 19, 2004 11:4